Protein Details: Voltage-gated potassium channel subunit beta-2

Protein ID

ICDB_Pro_0663

Protein Name

Voltage-gated potassium channel subunit beta-2

Gene Name

Kcnab2; Ckbeta2; Kcnb3

Organism

Rattus norvegicus (Rat)

Length

367 amino acids

AlphaFoldDB

AF-P62483-F1-model_v4.pdb

Function

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling; and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane; and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Modulates the functional properties of KCNA4. Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal; 9;10-phenanthrenequinone; prostaglandin J2; 4-nitrobenzaldehyde; 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro)

Sequence

MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS

PDB Structures

1EXB 1QRQ 2A79 2R9R 3EAU 3EB3 3EB4 3LNM 3LUT 4JTA 4JTC 4JTD 5WIE 6CI1 6EBK 6EBL 7SIT 7SIZ

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

56;57;63;85;158;188;189;214;243;244;245;246;247;248;254;262;264;323;325;329;332;333

Disease

Location

Detected in brain (PubMed:21357749; PubMed:9334400). Detected in the middle third of the molecular layer of the dentate gyrus in hippocampus (PubMed:9334400). Detected in neurons in the deep cerebellar nucleus (PubMed:23318870). Detected in globus pallidus and pars reticulata of the substantia nigra (PubMed:9334400). Detected in cerebellum (PubMed:23318870). Detected at axon terminal plexuses of cerebellar granule cells (PubMed:9334400). Detected in the juxtaparanodal region of nodes of Ranvier in cerebellum (at protein level) (PubMed:9334400). Detected in mesenteric arteries (PubMed:15618540). s

DOI ID

10.1038/369289a0; 10.1523/jneurosci.17-21-08246.1997; 10.1111/j.1469-7793.1998.325be.x; 10.1126/science.285.5433.1565; 10.1074/jbc.m005010200; 10.1002/1096-9861(20000101)429:1<166::aid-cne13>3.0.co;2-y; 10.1016/s0014-5793(03)00705-1; 10.1161/01.res.0000154070.06421.25; 10.1074/jbc.c500237200; 10.1007/s11064-006-9056-4; 10.1021/bi800301b; 10.1074/jbc.m708875200; 10.1083/jcb.201007113; 10.1523/jneurosci.2634-10.2011; 10.1038/ncomms1871; 10.1113/jphysiol.2012.249706; 10.1016/s0092-8674(00)80805-3; 10.1126/science.289.5476.123; 10.1126/science.1116269; 10.1038/nature06265; 10.1038/nchembio.114; 10.1073/pnas.1000142107; 10.1126/science.1185954; 10.7554/elife.00594

RefSeq

NP_059000.1